A tool to visualize physicochemical sequence properties of biological macromolecules.
Structure, dynamics and, ultimately, biological function of proteins and nucleic acids are determined by the physicochemical properties of their primary sequences. Such properties are frequently captured via one-dimensional profile plots depicting a given physicochemical variable as a function of sequence position. Here, we present VOLPES, a user-friendly webserver and the associated JavaScript library that enable a fully interactive, multifunctional visualization, analysis and comparison of the physicochemical properties of protein and nucleic-acid sequences, allowing unprecedented insight into raw sequence data and creating a starting point for further in-depth exploration. Over 600 different amino acid and nucleobase properties are available through the interface (many sourced from the AAIndex [1]) to get your analysis started right away.
Are you a new user or a returning user who wants some additional instructions? We set up a tutorial page for you explaining the usage of VOLPES in detail.
Fancy a real-world illustration of VOLPES in action? Check out these interactive examples, play around and get a feel for what this tool is all about!